Disambiguating the optic nerve from the surrounding cerebrospinal fluid: Application to MS-related atrophy
| Autor: | Lindsey M. Dethrage, Robert L. Harrigan, Siddharama Pawate, Louise A. Mawn, Gabriela Caires, Robert L. Galloway, Frederick W. Bryan, Andrew J. Plassard, Bennett A. Landman, Seth A. Smith |
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| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test business.industry Multiple sclerosis Magnetic resonance imaging medicine.disease 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Atrophy Coronal plane Optic nerve Medicine Radiology Nuclear Medicine and imaging Optic neuritis Segmentation business 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | Magnetic Resonance in Medicine. 75:414-422 |
| ISSN: | 0740-3194 |
| Popis: | Purpose Our goal is to develop an accurate, automated tool to characterize the optic nerve (ON) and cerebrospinal fluid (CSF) to better understand ON changes in disease. Methods Multi-atlas segmentation is used to localize the ON and sheath on T2-weighted MRI (0.6 mm3 resolution). A sum of Gaussian distributions is fit to coronal slice-wise intensities to extract six descriptive parameters, and a regression forest is used to map the model space to radii. The model is validated for consistency using tenfold cross-validation and for accuracy using a high resolution (0.4 mm2 reconstructed to 0.15 mm2) in vivo sequence. We evaluated this model on 6 controls and 6 patients with multiple sclerosis (MS) and a history of optic neuritis. Results In simulation, the model was found to have an explanatory R-squared for both ON and sheath radii greater than 0.95. The accuracy of the method was within the measurement error on the highest possible in vivo resolution. Comparing healthy controls and patients with MS, significant structural differences were found near the ON head and the chiasm, and structural trends agreed with the literature. Conclusion This is a first demonstration that the ON can be exclusively, quantitatively measured and separated from the surrounding CSF using MRI. Magn Reson Med, 2015. © 2015 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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