Thermoanalytical studies on complexes of ketoconazole with cyclodextrin derivatives
| Autor: | Zoltán Aigner, Mihály Kata, Filiz Taneri, Ottó Berkesi, Tamer Güneri |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
chemistry.chemical_classification
Cyclodextrin Chemistry Infrared spectroscopy Condensed Matter Physics Inclusion compound chemistry.chemical_compound Differential scanning calorimetry X-ray crystallography medicine Organic chemistry Ketoconazole Physical and Theoretical Chemistry Thermal analysis Spectroscopy medicine.drug |
| Zdroj: | Journal of Thermal Analysis and Calorimetry. 74:769-777 |
| ISSN: | 1388-6150 |
| Popis: | Inclusion complexation between cyclodextrin derivatives (hydroxypropyl-β-cyclodextrin and methyl-β-cyclodextrin) and a very poorly water-soluble antifungal agent, ketoconazole, was studied. Solid products were prepared by physical mixing, kneading and spray-drying methods in four molecular ratios: 2:1, 1:1, 1:2 and 1:3. The possibility of complex formation between the drug and the cyclodextrins was studied by thermal analysis. Supplementary techniques, such as X-ray diffractometry and Fourier transformation-infrared spectroscopy, were also applied to interpret the results of the thermal study of the products. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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