O121 Signal-induced proliferation-associated protein 1 (SIPA1) expression in gastric cancer, clinical and prognostic value
| Autor: | R Y Yu, T A Martin, A X Li, E K Ji, S Jia, J Ji, W G Jiang |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | British Journal of Surgery. 110 |
| ISSN: | 1365-2168 0007-1323 |
| DOI: | 10.1093/bjs/znad101.121 |
| Popis: | Introduction SIPA1 (Signal-Induced Proliferation-Associated Protein 1) is a mitogen induced GTPase activating protein and known to regulate cycle progression and barrier function of cancer cells. It is reported to influence the disease progression in lung and colorectal cancers. Here, we report the clinical and prognostic value of SIPA1 in gastric cancer. Methods Two independent gastric cancer cohorts were tested for SIPA1 expression. The expression profile of SIPA1 was analysed against the clinical, pathological, outcome and the expression of the ERBB (Her) family members in the same cohorts. Results Gastric tumour tissues had a higher level of SIPA1 transcript than normal stomach tissues. High levels of SIPA1 were seen in high grade, node positive and high TNM tumours. SIPA1 had a significant correlation with the ERBB family members in both normal tissues and in tumour tissues. SIPA1 levels only had a weak relationship with the overall (OS) and disease free (DFS) survival. However, stratification of patients by expression pattern of ERBB3 (Her3), the ERBB family significantly correlated with SIPA1 (p Conclusion SIPA1 expression is frequently seen in gastric cancer and together with members of the ERBB family influences the clinical outcome and responses to chemotherapies of the patients. |
| Databáze: | OpenAIRE |
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