Autoradiographic Distribution of Binding Sites for Iodinated Tachykinins in the Rat Central Nervous System

Autor:	Elizabeth Burcher, C. W. Shults, T. L. Q’Donohue, S. H. Buck, Cinda J. Helke
Rok vydání:	1987
Předmět:	medicine.medical_specialty Central nervous system Substance P chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Biochemistry Internal medicine medicine Distribution (pharmacology) Binding site Tachykinin receptor Receptor Peptide ligand
Zdroj:	Substance P and Neurokinins ISBN: 9781461291091
Popis:	Tritiated and iodinated tachykinin peptide ligands bind to distinctly different types of sites in the CNS. Iritiated substance P (SP) and 125I-Bolton-Hunter reagent-labeled SP bind specifically to sites with higher affinity for SP and physa1aemin (PHYS) than for other tachykinins which has led to these being designated P-type sites. The biochemical regu1ation 0f these sites, their specificity, and their localization to CNS regions that are sensitive to the biological effects of SP suggest that the sites are SP receptors [see 1,2].
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b82678444169b2ad4ca94570a6bf66cd https://doi.org/10.1007/978-1-4612-4672-5_33 Zobrazit plný text záznamu