DNA/ANTI-DNA complexes
| Autor: | Ronald P. Taylor, Mark Johns, Steven J. Waller, Eleanor L. Wright, Kathi W. Morley |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Anti dna
biology Ligand binding assay Immunology Glomerulonephritis medicine.disease Molecular biology Pathogenesis chemistry.chemical_compound Immune system Rheumatology chemistry immune system diseases medicine biology.protein Immunology and Allergy Pharmacology (medical) Antibody skin and connective tissue diseases DNA |
| Zdroj: | Arthritis & Rheumatism. 24:651-657 |
| ISSN: | 1529-0131 0004-3591 |
| DOI: | 10.1002/art.1780240504 |
| Popis: | The hydrodynamic sizes of antibody/3H-dsDNA immune complexes are correlated with their ability to fix complement in a red blood cell-complement linked binding assay. The results with PM2 dsDNA and a sonicated preparation (with a molecular weight of approximately 5 . 105) suggest that packing considerations are also important in the complement binding reaction. The relevance of these findings with respect to the role of antibody/dsDNA immune complexes in the pathogenesis of glomerulonephritis in systemic lupus erythematosus is discussed. |
| Databáze: | OpenAIRE |
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