Treatment with DNAse I fosters binding to nec PBMC of CRP

Autor:	Ricardo A. Chaurio, Daniela Weidner, Ahmed Sheriff, Luis E. Muñoz, Christine Schorn, Georg Schett, Christina Janko, Kerstin Sarter
Rok vydání:	2009
Předmět:	immune system diseases Inflammatory marker Immunology Immunology and Allergy In patient Biology skin and connective tissue diseases Peripheral blood mononuclear cell Complement (complexity)
Zdroj:	Autoimmunity. 42:286-288
ISSN:	1607-842X 0891-6934
DOI:	10.1080/08916930902828197
Popis:	CRP is an important inflammatory marker, however, CRP levels are relatively low in patients with SLE. In addition patients with SLE often display low activities and serum levels for DNase I and complement, respectively. Here we show that DNase I treatment of nec PBMC increased their binding of CRP. Consequently, reduced DNase I activity in patients with SLE may contribute to the impaired opsonisation by CRP of dead cells, exacerbating the clearance defect in SLE of apo and nec cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b81bce41b97ebd38079324000ed82c39 https://doi.org/10.1080/08916930902828197 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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