The Iberian pig fed with high-fat diet: a model of renal disease in obesity and metabolic syndrome
| Autor: | Esteban Porrini, Consolacion Garcia-Contreras, José Luis Pesantez, Ana Rodríguez-Rodríguez, Antonio Gonzalez-Bulnes, Susana Astiz, Marta Vazquez-Gomez, Beatriz Isabel, Eduardo Salido-Ruiz, Sergio Luis-Lima, Javier Donate Correa, Rosa Rodríguez Rodríguez, Jorge González |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics business.industry Cholesterol Endocrinology Diabetes and Metabolism Saturated fat Medicine (miscellaneous) Renal function 030209 endocrinology & metabolism Context (language use) medicine.disease Obesity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Insulin resistance chemistry Internal medicine Medicine 030212 general & internal medicine Metabolic syndrome business Glomerular hyperfiltration |
| Zdroj: | International Journal of Obesity. 44:457-465 |
| ISSN: | 1476-5497 0307-0565 |
| Popis: | Background: The pathogenesis of renal disease in the context of overweight/obesity, metabolic syndrome, and insulin resistance is not completely understood. This may be due to the lack of a definitive animal model of disease, which limits our understanding of obesity-induced renal damage. We evaluated the changes in renal histology and lipid deposits induced by obesity in a model of insulin resistance: the Iberian swine fed with fat-enriched food. Methods: Twenty-eight female sows were randomized to standard (SD) or high-fat diet (HFD: 6.8% of saturated fat) for 100 days. Weight, adiposity, analytics, oral glucose tolerance tests, and measured renal function were determined. Renal histology and lipid deposits in renal tissue were analyzed. Results: Animals on HFD developed obesity, hypertension, high levels of LDL cholesterol, triglycerides, insulin resistance, and glomerular hyperfiltration. No animal developed overt diabetes. Animals on HFD showed “diabetoid changes”, including mesangial expansion [21.40% ± 4 vs.13.20% ± 4.0, p < 0.0001], nodular glomerulosclerosis [7.40% ± 7, 0.75 vs. 2.40% ± 4.7, p = 0.02], and glomerulomegaly (18% vs. 10%, p = 0.010) than those on SD. Tubular atrophy, interstitial fibrosis, inflammation, arteriolar hyalinosis, or fibrointimal thickening were mild and similar between groups. Triglyceride content in renal tissue was higher in animals on HFD than in SD (15.4% ± 0.5 vs. 12.7% ± 0.7; p < 0.01). Conclusions: Iberian pigs fed with fat-enriched food showed diabetoid changes and glomerulomegaly as observed in obese humans making this model suitable to study obesity-induced renal disease. |
| Databáze: | OpenAIRE |
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