| Popis: |
Hepatic disorders are progressed by oxidative stress, chronic inflammation, hepatocyte death and increased transforming growth factor. Herein we investigated the phytochemical screening of green tea (Camellia sinensis) and analyzed its anti-oxidant and anti-inflammatory potential on liver biomarkers that elaborate therapeutic efficacy of polyphenols (catechins) in rat model associated with CCl4 induced liver injury along high fat diet. Pro-inflammatory cytokines are stimulated by either acute or chronic liver injury and critically triggered the production of inflammation, steatosis, fibrosis and liver carcinoma. We designed HPLC work to isolate the green tea phytochemical constituents quantitatively in a remarkable therapeutic range. Anti-inflammatory and antioxidant activities were carried out in vivo using treatment with green tea polyphenol extract (GTPE 600 mg/kg) that significantly reduced (P |
