EVALUATION OF A GROUP OF PYRROLE DERIVATIVES AS TUBERCULOSTATIC AGENTS

Autor:	Stanislava Vladimirova, Maya Georgieva, Atanas Bijev, Diana Tzankova
Rok vydání:	2017
Předmět:	Tuberculosis biology Stereochemistry Chemistry Ocean Engineering biology.organism_classification medicine.disease Combinatorial chemistry Pyrrole derivatives Mycobacterium tuberculosis Drug likeness medicine Lipinski's rule of five Pharmacophore Tuberculostatic Agents
Zdroj:	CBU International Conference Proceedings. 5:1083-1091
ISSN:	1805-9961 1805-997X
DOI:	10.12955/cbup.v5.1075
Popis:	This research aims to contribute to the global search for more effective tuberculostatics that has been triggered by recent outbreaks of tuberculosis. A group of pyrrole-containing derivatives are designed and theoretically elucidated. The identification of the pharmacophore group using the PharmaGist webserver is attempted. Also, the corresponding drug-like properties of the tested compounds are evaluated, together with their possible toxicity risks. The pharmacokinetic behavior of the structures is predicted, based on the Lipinski’s Rule of Five. The effects of some structural parameters are tested. In addition, in vitro evaluations of the anti-tubercular activity against Mycobacterium tuberculosis H37Rv are performed, with compound GA-9 registering the highest activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b817e85a3ccabe6bc485d044b145bbb6 https://doi.org/10.12955/cbup.v5.1075 Zobrazit plný text záznamu