Noncovalent Catalysis for Enantioselective Direct Aldol Reaction of 3‐Acetylcoumarins to Pyrazole‐4,5‐diones

Autor:	Soumya Singha Roy, Santanu Mukherjee, Bidisha Ray
Rok vydání:	2019
Předmět:	010405 organic chemistry Chemistry Organic Chemistry Enantioselective synthesis Substrate (chemistry) Pyrazole 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Bifunctional catalyst Catalysis Stereocenter chemistry.chemical_compound Aldol reaction Bifunctional
Zdroj:	Asian Journal of Organic Chemistry. 8:1045-1048
ISSN:	2193-5815 2193-5807
Popis:	The first catalytic enantioselective direct aldol reaction of 3-acetylcoumarins to pyrazole-4,5-diones is reported and shown to proceed through noncovalent substrate activation by a quinine-derived bifunctional tertiary amino-amide as the catalyst. The densely functionalized products, consisting of an oxygen-containing quaternary stereocenter and bearing two biologically relevant heterocycles, are generally obtained in high yields with moderate to excellent enantioselectivities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b8139f3d6f0455076efa23cd58811e57 https://doi.org/10.1002/ajoc.201800732 Zobrazit plný text záznamu Plný text