CORRECTION OF MICRONUTRIENT STATUS OF THE POPULATION OF THE IRKUTSK REGION AS A MEANS OF LOWERING INFANT MORTALITY
| Autor: | Tatiana Spasich, Lyubov' Reshetnik, Tatiana Boyko, Maria Grigorieva, Irina Kozlovskaya |
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| Rok vydání: | 2018 |
| Předmět: |
Pregnancy
medicine.medical_specialty General Immunology and Microbiology business.industry Perinatal mortality Incidence (epidemiology) medicine.disease Iodine deficiency Gastroenterology General Biochemistry Genetics and Molecular Biology Infant mortality Pediatric tuberculosis Folic acid Internal medicine medicine Vitamin D and neurology business |
| Zdroj: | Acta biomedica scientifica. 2:37-42 |
| ISSN: | 2587-9596 2541-9420 |
| Popis: | Aim: to establish a link between the level of folic acid, vitamin D and iodine consumption, and infant and perinatal mortality, morbidity of childhood tuberculosis in the Irkutsk region. Consumption of folate in the form of a single-agent preparation increased 3 times in 5 years. Consumption of folic acid in women at the stage of preconception and pregnancy affected the reduction of perinatal (R = –0.9; p = 0.016) and infant (R = –0.89; p = 0.04) mortality, including neonatal (R = –0.89; p = 0.039). Preventive supplementation of vitamin D of people in the region over the past 5 years has increased by 70 %, and infant mortality fell by 35.5 %. Infant (R = –0.94; p = 0.01) and especially post-neonatal (R = –0.97; p = 0.004) mortality are controllable and depend on the prevention of hypovitaminosis D. The understanding of the role of vitamin D in trigger- ing the synthesis of the antimicrobial peptide cathelicidin opens prospects for using it as a medicine for prevention and treatment of childhood tuberculosis. The incidence of pediatric tuberculosis in the region during this period decreased by 46 % (R = –0.95; p = 0.01). Correction of iodine deficiency in pregnant women and children caused the reduction of perinatal (R = –0.99; p = 0.07), early neonatal (R = –0.99; p = 0.05), neonatal (R = –0.98; p = 0.06) and post-neonatal (R = –0.99; p = 0.002) infant mortality. |
| Databáze: | OpenAIRE |
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