Synthesis of ({8-[4,6-Bis-(bis-pyridin-2-ylmethyl-amino)-[1,3,5]triazine-2-ylamino]-octyl}—ethoxycarbonylmethyl-amino)-acetic acid ethyl ester
| Autor: | Burkhard König, Daniel Vomasta |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
chemistry.chemical_classification
Iminodiacetic acid Organic Chemistry chemistry.chemical_element Zinc Biochemistry Medicinal chemistry Amino acid Metal Acetic acid chemistry.chemical_compound chemistry 1 3 5-Triazine Dipicolylamine visual_art visual_art.visual_art_medium Organic chemistry Physical and Theoretical Chemistry Histidine |
| Zdroj: | Molbank. 2007:M557 |
| ISSN: | 1422-8599 |
| DOI: | 10.3390/m557 |
| Popis: | Dipicolylamine, 2,4,6-tris-chloro-triazine, iminodiacetic acid, two-prong Combination of recognition units in synthetic receptors typically increases binding constants, if cooperativityoccurs.[1] Dipicolylamine (Dpa) bis-zinc complexes are known to bind phosphate-dianions under physiologicalconditions with good affinities [2,3], whereas metal(II)-imino-diacetate (M(II)-IDA) complexes (metal(II) =copper(II), nickel(II) or zinc(II)) show affinity to N-terminal histidine.[2] Combining both units may lead to aselective binding of phosphorylated amino acid bearing N-terminal histidine. We report here a general syntheticroute to ligands bearing a Dpa and an Ida site for metal ion complexation. The use of 6-chloro-N,N,N',N'-tetrakis-pyridin-2-ylmethyl-[1,3,5]triazine-2,4-diamine ( |
| Databáze: | OpenAIRE |
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