Cryptorchidism and varicocele: аnother look at the reasons for launching autoaggression

Autor:	V.V. Chopyak, A.I. Nakonechnyi, M. Kurpisz, M. Fraczek, I.A. Nakonechnyi, A.M. Havrylyuk
Rok vydání:	2017
Předmět:	Infertility medicine.medical_specialty business.industry Varicocele Urology Inflammation Unilateral cryptorchidism medicine.disease medicine.disease_cause Sperm Pathogenesis Blood serum Medicine medicine.symptom business Oxidative stress
Zdroj:	Paediatric Surgery. Ukraine. 56:75-83
ISSN:	2521-1358 2304-0041
DOI:	10.15574/ps.2017.56.75
Popis:	Objective. To determine the role of oxidative stress and inflammation in the pathogenesis of subfertility/infertility and formation of autoimmunity in patients with cryptorchidism and varicocele. Material and metods. Blood levels of MDA and IL-6 were measured in 48 boys with cryptorchidism and 20 healthy subjects. The spermal parameters (motility, morphology), blood levels of MDA and IL-6 were measured in 22 men with varicocele and 21 healthy subjects. The statistical processing was performed with using noparametrical methods and standart computer programs (Statistica Version 6, StatSoft, Inc.; SPSS Statistics 17.0, IBM). Results. We showed that the level of МDA was significantly higher in blood of the cryptorchidism group compared with the control group (p=0.003). The blood serum concentration of IL-6 in the group with bilateral cryptorchidism as compared to the group with unilateral cryptorchidism was higher (p=0.001). We revealed that the levels of MDA, IL-6 and seminal parameters (low motility, sperm abnormalities) was higher in patients with varicocele compared to the control group (p
Databáze:	OpenAIRE
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