Quantitative Reduction in the Dynamic Endothelial Function on Foot Microcirculation in Patients with Diabetes Mellitus
| Autor: | Wei-Kung Tseng, Hsin-Yen He, Xuan-Hao Su, Jia-Jung Wang, G. Hung |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
business.industry Provocation test 030204 cardiovascular system & hematology Laser Doppler velocimetry medicine.disease 01 natural sciences Microcirculation 010309 optics 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Diabetes mellitus Internal medicine 0103 physical sciences Occlusion medicine Cardiology Ankle Endothelial dysfunction business Reactive hyperemia |
| Zdroj: | IFMBE Proceedings ISBN: 9783030306359 |
| DOI: | 10.1007/978-3-030-30636-6_39 |
| Popis: | Microvascular perfusion on the foot bottom in 39 subjects (Control group: 23 healthy participants; Patient group: 16 patients with diabetes mellitus) was measured with the laser Doppler flowmetry (LDF). Each subject was requested to perform a non-invasive provocation of 37 min, including 8-min baseline, 3-min ankle occlusion, 6-min post-occlusive reactive hyperemia (PORH), and 20-min heating (42 °C) period. By using the wavelet transform, we calculated the power spectral densities (PSD), on one-minute basis, of the 37-min LDF signal. The results indicated that the PSD corresponding to the endothelial NO-independent (PSDENDO1) and NO-dependent (PSDENDO2) metabolic activities varied with time in both Control and Patient groups. Patient group showed less PSDENDO1 and PSDENDO2 than those in Control group. In summary, endothelial dysfunction in peripheral microcirculation exists in diabetes patients, apparently as compared with healthy participants. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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