Enantiomerically enriched (R)- and (S)-α-methylphenylalanine via asymmetric PTC C-alkylation catalysed by NOBIN
Autor: | N. S. Ikonnikov, Konstantin A. Kochetkov, Tatiana D. Churkina, Henri B. Kagan, Yuri N. Belokon, Stepan Vyskocil |
---|---|
Rok vydání: | 1999 |
Předmět: | |
Zdroj: | Tetrahedron: Asymmetry. 10:1723-1728 |
ISSN: | 0957-4166 |
Popis: | Enantiopure 2-hydroxy-2′-amino-1,1′-binaphthyl (NOBIN) is shown to catalyse C-alkylation of aldimine Schiff's bases of alanine ester under phase-transfer catalysis conditions (solid NaOH or NaH, toluene, ambient temperature, 10% NOBIN). Using (R)-NOBIN, the final (S)-α-methylphenylalanine was obtained in up to 68% ee. |
Databáze: | OpenAIRE |
Externí odkaz: |