Evaluation of Antidiabetic Effect of Ethanolic Leaves Extract of Becium grandiflorum Lam. (Lamiaceae) in Streptozotocin-Induced Diabetic Mice
| Autor: | Leake Gebremeskel, Kald Beshir Tuem, Tewolde Teklu |
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| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
biology Traditional medicine business.industry Negative control 030209 endocrinology & metabolism Diabetic mouse 030204 cardiovascular system & hematology Body weight biology.organism_classification Streptozotocin medicine.disease Glibenclamide 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal Medicine medicine Lamiaceae Analysis of variance business medicine.drug |
| Zdroj: | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13:1481-1489 |
| ISSN: | 1178-7007 |
| Popis: | Background Becium grandiflorum has been used traditionally for treatment of different ailments including diabetes mellitus although it lacks scientific evidence. Thus, the present study was aimed at evaluating the antidiabetic effect of Becium grandiflorum in streptozotocin (STZ) -induced diabetic mice. Methods The antidiabetic activity of hydro-ethanolic (30:70) leaf extract of Becium grandiflorum was evaluated in STZ (45 mg/kg) -induced diabetic and normal mice. Antihyperglycemic, hypoglycemic, oral glucose tolerance and body weight change effects of the extract were assessed after administering three doses of the extract (200, 400 and 600 mg/kg), glibenclamide 5 mg/kg (reference drug) and 2% Tween 80 (vehicle). One-way analysis of variance and Tukey's post hoc test were used for data analysis. Results All doses of the extract (200 mg/kg (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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