Physical activity releases prostate-specific antigen (PSA) from the prostate gland into blood and increases serum PSA concentrations
| Autor: | U B Seiffert, G M Oremek |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
biology business.industry Biochemistry (medical) Clinical Biochemistry Acid phosphatase Physical exercise urologic and male genital diseases medicine.disease Prostate-specific antigen Prostate cancer Endocrinology medicine.anatomical_structure Antigen Prostatic acid phosphatase Prostate Internal medicine medicine biology.protein business Blood sampling |
| Zdroj: | Clinical Chemistry. 42:691-695 |
| ISSN: | 1530-8561 0009-9147 |
| DOI: | 10.1093/clinchem/42.5.691 |
| Popis: | Determination of prostate-specific antigen (PSA) is an established tool in detecting prostate cancer. However, the effect of physical activity on the PSA concentration in serum is controversial. We measured serum concentrations of PSA and prostatic acid phosphatase (PAP) in 301 healthy outpatients before and after they performed standardized exercise. Immediately after 15 min of exercise on a bicycle ergometer, their serum PSA concentrations increased by as much as threefold. The increase was age dependent and correlated to the PSA concentration before exercise. This increase was evident in both the free and complexed fractions of PSA. The amount of PSA secreted into blood depends on the volume of the prostate, whereas productivity of the prostate epithelium remains constant or increases slightly with age. We present cutoff values for clinical use. PAP was also increased, but to a lesser extent. The PSA and PAP secretion mechanisms differ. Our data suggest that extensive physical activity should be avoided before blood sampling for diagnostic purposes and, in case of an increase, the PSA concentration should be controlled after an exercise test. |
| Databáze: | OpenAIRE |
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