Effects of Achieving an LDL-Cholesterol Level of <70 mg/dL Compared With the Goal of <100 mg/dL Using Simvastatin or Atorvastatin on Cognitive Processes in High-Risk Diabetic Patients
| Autor: | Mehmet Asik, Banu Cangoz, Ayse Canan Yazici, Metin Karatas, Nilgun Guvener, Zehra Berberoglu |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Ldl cholesterol
medicine.medical_specialty Statin Cholesterol business.industry medicine.drug_class Endocrinology Diabetes and Metabolism Atorvastatin Cognition Pharmacology medicine.disease Gastroenterology chemistry.chemical_compound chemistry Simvastatin Internal medicine Diabetes mellitus medicine lipids (amino acids peptides and proteins) business medicine.drug Lipoprotein |
| Zdroj: | The Endocrinologist. 19:271-279 |
| ISSN: | 1051-2144 |
| DOI: | 10.1097/ten.0b013e3181c052fa |
| Popis: | We aimed to compare the effects of an low-density lipoprotein (LDL)-cholesterol level of 70 mg/dL versus the goal of 100 mg/dL using simvastatin or atorvastatin on cognition. In this open-label trial, patients with diabetes were randomly assigned to simvastatin or atorvastatin 10 mg. If LDL-cholesterol levels, monitored at 30-day intervals, were 100 mg/dL, the doses of simvastatin and atorvasta- tin were increased to a maximum of 40 and 80 mg, respectively. Within each treatment group, patients were stratified by achieved LDL-cholesterol goals into 2 subgroups. Cognitive function was assessed using neuropsychological tests and event-related potential P300 at baseline and after 12 weeks. One hundred fourteen subjects completed the study. The mean LDL- cholesterol levels after simvastatin therapy was 60.2 mg/dL in the subgroup with LDL-cholesterol 70 mg/dL (n 28) and 87.4 mg/dL in the subgroup with levels between 70 and 100 mg/dL (n 29). After atorvastatin, mean LDL-cholesterol was 55.6 mg/dL in the subgroup with LDL-cholesterol 70 mg/dL (n 30) compared with 86.8 mg/dL in the other subgroup (n 27). In the simvastatin subgroup with LDL-cholesterol 70 mg/dL, significant performance decrements on neuropsychological tests of visuospatial percep- tion, orientation, and minor improvement of immediate recall were noted. Executive functions, visuospatial organization worsened also with atorvasta- tin use. Minor improvement in short-term memory occurred in the atorva- statin subgroup with LDL-cholesterol levels of 70 to 100 mg/dL. No correlation existed between the changes in LDL-cholesterol levels and neuropsychological findings in all groups. This study provided partial support for decrements in cognitive function- ing with simvastatin and atorvastatin regardless of achieved LDL-cholesterol goals. The clinical importance, however, is uncertain. However, a mild improvement in short-term memory after the use of both agents could not be excluded. |
| Databáze: | OpenAIRE |
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