Role of Catecholamines in the Central Actions of Medroxyprogesterone Acetate1)
| Autor: | Barthwal Jp, Krishna P. Bhargava, P. L. Tandon, Gupta Tk, M.L. Gupta |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Medroxyprogesterone Central nervous system Biological activity General Medicine Biology chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Dopamine Internal medicine Internal Medicine medicine Catecholamine Medroxyprogesterone acetate skin and connective tissue diseases Neurotransmitter Depression (differential diagnoses) medicine.drug |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 82:380-383 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-0029-1210303 |
| Popis: | The role of catecholamines in the mechanism of antiovulatory and other central effects of medroxyprogesterone acetate (MPA) has been studied in adult healthy, non-pregnant female albino rats. It has been observed that a single dose of MPA (100 mg/kg) given intramuscularly did not cause any significant change in brain catecholamine levels after 7 days of treatment. However, there was a significant reduction in brain dopamine levels after 15 days of MPA administration. This reduction in brain dopamine levels may be responsible for the anti-ovulatory activity of MPA. Certain side effects of MPA such as amenorrhoea, galactorrhoea, breast tenderness, breast tumors, inactivity and depression may also be due to decrease in brain dopamine levels. |
| Databáze: | OpenAIRE |
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