ChemInform Abstract: A Temporary-Bridge Strategy for Enantioselective Organocatalyzed Synthesis of Aza-Seven-Membered Rings

Autor:	Sébastien Goudedranche, Thierry Constantieux, Damien Bonne, Jean Rodriguez, David Pierrot
Rok vydání:	2015
Předmět:	Annulation chemistry.chemical_compound Azepane chemistry Stereochemistry Organocatalysis Electrophile Enantioselective synthesis General Medicine Optically active Domino
Zdroj:	ChemInform. 46
ISSN:	0931-7597
DOI:	10.1002/chin.201518233
Popis:	We report the first enantioselective organocatalyzed domino synthesis of azepane moieties. This temporary-bridge strategy is based on a conceptually original annulation of ambident electrophilic and 1,4-bis-nucleophilic α-ketoamides with 1,3-bis-electrophilic enals. The obtained oxygen-bridged azepanes can be selectively transformed into optically active azepanone, azepanol or azepanedione derivatives of high synthetic value.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b7f5af26237fbea381224e39ff2248dc https://doi.org/10.1002/chin.201518233 Zobrazit plný text záznamu Plný text