Early signs of autism in infants whose mothers suffered from a threatened preterm labour: a 30-month prospective follow-up study
| Autor: | Rosa Sahuquillo-Leal, Laura Pina-Camacho, Alba Moreno-Giménez, Vicente Diago, Máximo Vento, Ana García-Blanco, Belén Almansa, Pablo Navalón, Farah Ghosn |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pediatrics media_common.quotation_subject Population 03 medical and health sciences 0302 clinical medicine Developmental and Educational Psychology medicine Child and adolescent psychiatry 0501 psychology and cognitive sciences education media_common Psychomotor learning education.field_of_study Pregnancy business.industry 05 social sciences General Medicine medicine.disease 030227 psychiatry Psychiatry and Mental health Autism spectrum disorder Pediatrics Perinatology and Child Health Anxiety Autism Temperament medicine.symptom business 050104 developmental & child psychology |
| Zdroj: | European Child & Adolescent Psychiatry. 31:1-13 |
| ISSN: | 1435-165X 1018-8827 |
| DOI: | 10.1007/s00787-021-01749-y |
| Popis: | Infants born after a threatened preterm labour (TPL infants) are at high risk of autism spectrum disorder (ASD). Studying this population may provide insight on the pathophysiological underpinnings of this condition. This study aimed to (i) ascertain the presence and autistic symptom load in TPL infants aged age 30 months relative to non-TPL infants, regardless of preterm birth; (ii) explore the association between early (at 6 months) psychomotor development and temperament features with the autistic symptom load of TPL infants at age 30 months and (iii) examine the association among perinatal risk factors for ASD development with the autistic symptom load of TPL infants at age 30 months. A group of 111 mother–infant pairs recruited at TPL diagnosis and a group of 47 healthy mother–infant controls completed the follow-up. Irrespective of preterm birth, TPL infants showed higher autistic symptom load at age 30 months than non-TPL infants. TPL infants presented poorer communication and problem-solving skills, reduced smiling and laughter, and greater vocal reactivity at age 6 months, predicting higher autistic symptom load at age 30 months. Higher levels of anxiety symptoms in TPL mothers after a TPL diagnosis also predicted higher autistic symptom load for the infants at age 30 months. These results suggest that TPL infants may be an undescribed cluster, with features that differentiate them from other “at-risk” populations. These findings support the need for routine assessment of TPL infants and screening of anxiety symptoms in mothers. |
| Databáze: | OpenAIRE |
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