Mechanisms of homocysteic acid neurotoxicity
| Autor: | E. S. Arzumanyan, M. S. Stepanova |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
chemistry.chemical_classification
Programmed cell death Reactive oxygen species Necrosis Neurotoxicity Carnosine Pharmacology medicine.disease Biochemistry Homocysteic acid Cellular and Molecular Neuroscience chemistry.chemical_compound chemistry Apoptosis medicine medicine.symptom Molecular Biology Intracellular |
| Zdroj: | Neurochemical Journal. 4:222-227 |
| ISSN: | 1819-7132 1819-7124 |
| DOI: | 10.1134/s1819712410030104 |
| Popis: | Homocysteine (HC) and a product of its spontaneous oxidation, homocysteic acid (HCA), are neurotoxic compounds; however, the mechanism of their neurotoxicity is unknown. We found that application of HCA to neurons results in an increase in the intracellular level of reactive oxygen species (ROS), activation of MAP kinase (MAPK) and, finally, in cell death. We found that HCA increases both cellular apoptosis and necrosis, whereas preliminary incubation of cells with carnosine protects cells from these types of cell death. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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