Immunological Detection and Isolation of a New Taxoid from the Stem Bark of Taxus baccata
| Autor: | Renée Vanhaelen-Fastré, Mondher El Jaziri, Yanwen Guo, Maurice Vanhaelen, Bilo Diallo, Robert Ottinger |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pharmacology
Stem bark Chromatography biology Organic Chemistry Pharmaceutical Science Pharmacognosy biology.organism_classification Terpenoid Analytical Chemistry Taxoid chemistry.chemical_compound Countercurrent chromatography Complementary and alternative medicine chemistry Taxus visual_art Drug Discovery visual_art.visual_art_medium Molecular Medicine Bark Diterpene |
| Zdroj: | Journal of Natural Products. 59:169-172 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np960043m |
| Popis: | The separation of a stem-bark extract of Taxus baccata L. cv. stricta by HSCCC resulted in several chromatographic fractions that were analyzed by ELISA using specific anti-10-deacetylbaccatin III antibodies. In addition to 10-deacetylbaccatin III and to four known xylosyl taxoids, a new taxoid, 9-deacetyl-9-benzoyl-10-debenzoyltaxchinin A (1), was isolated, and its structure was elucidated using spectroscopic methods. The cross-reactivity of 1 with anti-10-deacetylbaccatin III antibodies was examined. |
| Databáze: | OpenAIRE |
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