Morphological manifestations of anthracycline cardiomyopathy in the ventricular myocardium of rats
| Autor: | Semenov De, Semenova La, Nepomniashchikh Lm |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
education.field_of_study
medicine.medical_specialty Anthracycline business.industry Population Cardiomyopathy General Medicine medicine.disease General Biochemistry Genetics and Molecular Biology Ventricular myocardium medicine.anatomical_structure Ventricle Internal medicine medicine Cardiology Left ventricular myocardium education business |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 104:1018-1022 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00841928 |
| Popis: | Cardiomyopathy and plastic contractile myocardial insufficiency were simulated in Wistar rats by an anthracycline antibiotic rubomycin. The myocardium in conditions of DNA-dependent RNA synthesis suppression was studied using polarization, electron microscopy and the method of cardiomyocyte isolation. During anthracycline cardiomyopathy in the absence of necrotic and necrobiotic myocardial injuries there was a smaller depression of cardiomyocyte population and their nuclei in the right ventricle (23 and 22% respectively) than in the left ventricle (38 and 39% respectively). It was concluded that a smaller amount of cardiomyocyte population was in the phase of intensive protein synthesis in the right than in the left ventricular myocardium. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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