NFκB as a potent regulator of inflammation in human adipose tissue, influenced by depot, adiposity, T2DM status, and TNFα
| Autor: | Dara Al-Disi, Milan K. Piya, Philip G. McTernan, John C. Clapham, Nasser M. Al-Daghri, J. P. O'Hare, Thomas M. Barber, Warunee Kumsaiyai, Alison L. Harte, Sudhesh Kumar, Gyanendra Tripathi, Ponnusamy Saravanan, Anne E. Fowler |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics Chemistry Endocrinology Diabetes and Metabolism Regulator Medicine (miscellaneous) Adipose tissue Inflammation In vitro law.invention Endocrinology law Internal medicine medicine Recombinant DNA Tumor necrosis factor alpha Secretion medicine.symptom Intracellular |
| Zdroj: | Obesity. 21:2322-2330 |
| ISSN: | 1930-7381 |
| DOI: | 10.1002/oby.20336 |
| Popis: | OBJECTIVE: Central obesity and sub-clinical inflammation increase metabolic risk, this study examined the intracellular inflammatory pathways in adipose tissue (AT) that contribute to this risk. DESIGN AND METHODS: This study therefore addressed the influence of NFκB and JNK activation in human abdominal subcutaneous (AbdSc) and omental (Om) AT, the effect of adiposity, T2DM status and the role of TNFα in vitro, using molecular biology techniques. RESULTS: Our data showed NFκB activity is increased in Om AT versus AbdSc AT (P |
| Databáze: | OpenAIRE |
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