Association of leptin serum concentration with heart adipose tissue and parameters of systolic and diastolic function in heart failure patients

Autor:	P Jirak, Lukas J. Motloch, Z. Shomanova, Rudin Pistulli, C Granitz, Uta C. Hoppe, Holger Reinecke, B Ohnewein, C.A Pogoda, Michael Lichtenauer, E.J Froeb
Rok vydání:	2020
Předmět:	medicine.medical_specialty Endocrinology business.industry Heart failure Leptin Internal medicine medicine Adipose tissue Diastolic function Serum concentration Cardiology and Cardiovascular Medicine medicine.disease business
Zdroj:	European Heart Journal. 41
ISSN:	1522-9645 0195-668X
Popis:	Aims Leptin has recently been related to myocardial remodeling in animal experimentation studies on heart failure (HF). Furthermore, leptin has been reported to be related to diastolic dysfunction, however only in healthy population. With the emergence of new medical therapies targeting cardiac remodeling, there needs to be a better understanding of the metabolic pathways involving leptin. Our study aims to investigate leptin's correlation to parameters of systolic and diastolic heart function, as well as epicardial and pericardial adipose tissue (EAT and PAT) in heart failure (HF) patients. Methods The study included 51 patients with chronic heart failure with reduced ejection fraction (HFrEF) of ischemic (n=22) and non-ischemic (n=29) origin (NYHA II-III, mean EF 29.56%, SD 8.1; mean BMI 28.08, SD 5.8). Serum concentrations of leptin, NT-proBNP, HbA1c, LDL, and total cholesterol were also measured. Global longitudinal strain (GLS) and other LV function parameters were assessed in transthoracic echocardiography, as well as EAT and PAT in parasternal long and short-axis views. Results We found a significant correlation between leptin serum concentration and epicardial, as well as pericardial adipose tissue (EAT r=0.336, p=0.030; PAT r=0.565, p Conclusion We provide evidence of serum leptin correlation to remodeling parameters, as well as epicardial and pericardial fat tissue in HF patients. Whether leptin has positive effects on reversing or preventing remodeling in heart failure, needs further investigation. Correlation of leptin vs. GLS Funding Acknowledgement Type of funding source: None
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b7c0bca82208f1f1ee7236c9e5e597d7 https://doi.org/10.1093/ehjci/ehaa946.0915 Zobrazit plný text záznamu