Synthesis of GlcNAcp- β-(1→3)-Galp- α-(1→2)-6-deoxy-altroHepp- α-(1→O-propyl, an O-Antigenic Repeating Unit from C. jejuni O:23 and O:36

Autor:	Jeong E. Nam Shin, Shinsook Yoon, Keun Ho Chun, Youngsook Shin
Rok vydání:	2004
Předmět:	chemistry.chemical_classification biology Stereochemistry GalP Iodonium dicollidine Disaccharide General Chemistry biology.organism_classification Acceptor Campylobacter jejuni Perchlorate chemistry.chemical_compound chemistry Antigen biology.protein Trisaccharide
Zdroj:	Bulletin of the Korean Chemical Society. 25:289-292
ISSN:	0253-2964
DOI:	10.5012/bkcs.2004.25.2.289
Popis:	A trisaccharide, GlcNAcp-β-(1→3)-Galp-a-(1→2)-6-deoxy-altroHepp-α-(1→O-propyl, as an O-antigenic repeating unit of C. jejuni serotype 0:23 and 0:36 was synthesized. Coupling of the GlcNPhth-(1→3)-Gal disaccharide donor with allyl 6-deoxy-altroHep acceptor in the presence of iodonium dicollidine perchlorate (IDCP) promoter afforded the α-galactosidic trisaccharide with high stereoselectivities. Subsequent deacetalation, dephthaloylation, N-acetylation, and hydrogenolytic debenzylation furnished the title compound.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b7bb002d3f12a37ddc5dc32ad9a5ffcb https://doi.org/10.5012/bkcs.2004.25.2.289 Zobrazit plný text záznamu