112 Identification of Non-HLA Antibodies in Ventricular Assist Device Recipients
| Autor: | Duska Dragun, J. Garbade, Stefan Dhein, Sara Klein, S. von Salisch, Friedrich-Wilhelm Mohr, Markus J. Barten, Hartmuth B. Bittner, Maja-Theresa Dieterlen |
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| Rok vydání: | 2012 |
| Předmět: |
Pulmonary and Respiratory Medicine
Transplantation biology business.industry medicine.medical_treatment Autoantibody Human leukocyte antigen Major histocompatibility complex Pathogenesis Ventricular assist device Immunology biology.protein medicine Surgery Antibody Cardiology and Cardiovascular Medicine Endothelin receptor Receptor business |
| Zdroj: | The Journal of Heart and Lung Transplantation. 31:S46 |
| ISSN: | 1053-2498 |
| DOI: | 10.1016/j.healun.2012.01.116 |
| Popis: | Aims Recipients of ventricular assist devices (VADR) have a higher incidence to develop antibodies (Abs) against human leukocyte antigens (HLA). Non-HLA antibodies like major histocompatibility complex class I-related chain A (MICA) and autoantibodies against angiotensin type 1 receptor (AT1R) and endothelin receptor A (ETAR) are also implicated in the pathogenesis of acute rejection and allograft vasculopathy. We monitored non-HLAand HLA-Abs in VADR up to one year after implantation. |
| Databáze: | OpenAIRE |
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