FcγRIIα: sequencing of the ligand binding domain in systemic lupus erythematosus patients

Autor:	Susan W. Serjeantson, Paul A. Gatenby, E. C. Jazwinska, J. L. Banyer
Rok vydání:	1991
Předmět:	Lupus erythematosus biology Point mutation Immunology medicine.disease Ligand (biochemistry) Fragment crystallizable region Immune system IgG binding medicine biology.protein Immunology and Allergy Antibody Receptor
Zdroj:	Clinical and Experimental Immunology. 86:199-202
ISSN:	1365-2249 0009-9104
DOI:	10.1111/j.1365-2249.1991.tb05795.x
Popis:	SUMMARYThe receptor for the Fc portion of IgG (FcγR) is involved in the slow clearance of immune complexes. To perform this role it must be cross-linked by IgG bound in its extracellular domains. It has been suggested that defective FcγR-mediated clearance of immune complexes may play a role in the pathogenesis of autoimmune connective tissue disorders. We have sequenced DNA encoding the second extracellular domain of FcγRIIα in six patients with SLE, to investigate whether point mutations may be responsible for encoding a defect in the IgG binding capacity of the receptor. We were able to identify the point mutation which discriminates high and low responder genotypes but found no other change from the published DNA sequence for this region.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b79a49ff251819ce1de69da01261436d https://doi.org/10.1111/j.1365-2249.1991.tb05795.x Zobrazit plný text záznamu Plný text ve formátu PDF