The Difference in Effect of Predosing with Antiallergic Compounds between the Rat PCA Model and the Monkey Asthma Model

Autor:	Stewart Pb, El-Azab J
Rok vydání:	1977
Předmět:	Intravenous dose business.industry Immunology Disodium cromoglycate Immunology and Allergy Medicine General Medicine Pharmacology Asthma model Tachyphylaxis business
Zdroj:	International Archives of Allergy and Immunology. 55:343-349
ISSN:	1423-0097 1018-2438
DOI:	10.1159/000231945
Popis:	DSCG and PRD-92-Ea showed tachyphylaxis in the rat PCA test when a large intravenous dose (40 mg/kg of DSCG and 20 mg/kg of PRD-92-Ea) was given 30 min before administering intravenously the expected effective doses at the time of antigen challenge. This predosing led to a marked loss of effectiveness. Cross-reacting tachyphylaxis was also demonstrated in this model. Predosing rats with DSCG led to a great loss of effectiveness of a subsequent expected active dose of PRD-92-Ea and predosing with PRD-92-Ea had the same effect in preventing the antiallergic action of a subsequent dose of DSCG. The Rhesus monkey (Macaca mulatto) did not exhibit this phenomenon of tachyphylaxis. PRD-92-Ea and DSCG were given intravenously 30 min before and the same dose of 20 mg/kg repeated just before Ascaris suum challenge in the Rhesus monkey asthma model with no loss of their expected effectiveness.
Databáze:	OpenAIRE
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