Deep-vein thrombosis and coumarin skin necrosis associated with a factor V inhibitor with lupus-like features
| Autor: | Felix J.M. Van Der Meer, Pieter Willem Kamphuisen, Joost Haan, Peter C.M. Rosekrans |
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| Rok vydání: | 1998 |
| Předmět: |
Pathology
medicine.medical_specialty Lupus anticoagulant Low protein biology medicine.drug_class business.industry Deep vein Anticoagulant Factor V Hematology Bethesda unit medicine.disease Thrombosis medicine.anatomical_structure Endocrinology Internal medicine medicine biology.protein business Protein C medicine.drug |
| Zdroj: | American Journal of Hematology. 57:176-178 |
| ISSN: | 1096-8652 0361-8609 |
| DOI: | 10.1002/(sici)1096-8652(199802)57:2<176::aid-ajh14>3.0.co;2-a |
| Popis: | We report a 71-year-old man who developed deep-vein thrombosis after major surgery. Coumarin skin necrosis developed after starting oral anticoagulant therapy. An inhibitor to factor V (61 Bethesda units) with lupus-like features was found as well as a low protein C level. The occurrence of these very rare findings indicates that despite profound procoagulant inhibition (factor V inhibition and anticoagulant therapy), hypercoagulation can occur. |
| Databáze: | OpenAIRE |
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