Isoprenylated Phenolics from Roots of Artocarpus heterophyllus
Autor: | Yuan Qing Ding, Xiao Xiao Zhai, Yun Long Chen, Gang Ren, Chuan Yun Xiao, Wei Jiang |
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Rok vydání: | 2017 |
Předmět: | |
Zdroj: | Natural Product Communications. 12:1934578X1701200 |
ISSN: | 1555-9475 1934-578X |
Popis: | Thirteen compounds were isolated from Artocarpus heterophyllus, including one new di-isoprenylated stilbene, (±)-artoheterin A (1), and twelve known isoprenylated phenolics, artocarbene (2), 3′,5′,2,4-tetrahydroxy-4′-(3-methyl-2-butenyl) stilbene (3), cudrastilbene (4), 3-(3-methyl-2-butenyl) luteolin (5), 5,7,2′,4′-tetrahydroxy-6-(3-methyl-2-butenyl) flavone (6), 6-(3-methyl-2-butenyl) apigenin (7), artochamin B (8), 5′-hydroxycudraflavone A (9), artonins A and B (10–11), heterophyllin (12), and 8-(3-methyl-2-butenyl)-6,7-dihydroxycoumarin (13). The structures of these compounds were identified by spectroscopic methods. All isolated compounds were screened for their inhibitory abilities against cathepsin K (CatK). Of them, compounds 1–4 and 8–13 were found to have suppression capabilities against CatK with IC50 values ranging from 1.9 to 73.7 μM. |
Databáze: | OpenAIRE |
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