Isoprenylated Phenolics from Roots of Artocarpus heterophyllus

Autor:	Yuan Qing Ding, Xiao Xiao Zhai, Yun Long Chen, Gang Ren, Chuan Yun Xiao, Wei Jiang
Rok vydání:	2017
Předmět:	Pharmacology biology Traditional medicine 010405 organic chemistry Plant Science General Medicine biology.organism_classification Moraceae 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry Artocarpus Complementary and alternative medicine Drug Discovery
Zdroj:	Natural Product Communications. 12:1934578X1701200
ISSN:	1555-9475 1934-578X
Popis:	Thirteen compounds were isolated from Artocarpus heterophyllus, including one new di-isoprenylated stilbene, (±)-artoheterin A (1), and twelve known isoprenylated phenolics, artocarbene (2), 3′,5′,2,4-tetrahydroxy-4′-(3-methyl-2-butenyl) stilbene (3), cudrastilbene (4), 3-(3-methyl-2-butenyl) luteolin (5), 5,7,2′,4′-tetrahydroxy-6-(3-methyl-2-butenyl) flavone (6), 6-(3-methyl-2-butenyl) apigenin (7), artochamin B (8), 5′-hydroxycudraflavone A (9), artonins A and B (10–11), heterophyllin (12), and 8-(3-methyl-2-butenyl)-6,7-dihydroxycoumarin (13). The structures of these compounds were identified by spectroscopic methods. All isolated compounds were screened for their inhibitory abilities against cathepsin K (CatK). Of them, compounds 1–4 and 8–13 were found to have suppression capabilities against CatK with IC50 values ranging from 1.9 to 73.7 μM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b786b3871c1151c6522a2b7358efd1f2 https://doi.org/10.1177/1934578x1701200622 Zobrazit plný text záznamu