Effects of a Rebamipide Mouthwash on Stomatitis Caused by Cancer Chemotherapy —Evaluation of the Efficacy by Patients Themselves—
| Autor: | Naoko Ishii, Hideki Sakai, Yayoi Kawano, Norikazu Akizuki, Takehisa Hanawa, Masayo Komoda, Seitaku Hayashi |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pharmacology Chemotherapy medicine.medical_specialty Cancer chemotherapy business.industry medicine.medical_treatment Ethics committee Pharmaceutical Science Cancer medicine.disease Surgery 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Pain level Internal medicine medicine Rebamipide In patient business Stomatitis medicine.drug |
| Zdroj: | YAKUGAKU ZASSHI. 137:1027-1034 |
| ISSN: | 1347-5231 0031-6903 |
| Popis: | Anticancer drug-induced stomatitis develops in 30% to 40% of cancer cases that undergo chemotherapy. However, medications for this condition are not commercially available in Japan. Upon obtaining approval of the ethics committee, a mouthwash containing rebamipide as the active ingredient (rebamipide mouthwash) was administered to one inpatient and four outpatients, who had developed stomatitis caused by cancer chemotherapy. Starting from 14 d after the administration of the rebamipide mouthwash, the patients scored a stomatitis survey on oral state, pain level, and diet and recorded the number of times they gargled, as well as any stomatitis observations, in a stomatitis diary. The total scores for the points for each of the three types of survey sections were classified into Grades 0 to 4 and evaluated as a stomatitis evaluation score (SES). The SES became "0" in three out of the five patients within 14 d of treatment. No change in SES was found in one patient. In the remaining patients, SES became "0" once but increased again later. Using image analysis software (ImageJ), the area at which the stomatitis was observed was measured. When comparing SES and change in the area in patients who agreed to participate, gradual reductions in the extent of stomatitis was observed even during the period when SES did not change. Having patients fill in an observation chart was effective for grasping changes in symptoms in outpatients. |
| Databáze: | OpenAIRE |
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