Optimization of zinc oxide nanoparticle-catalyzed in vitro bilirubin photolysis and in vivo treatment of hyperbilirubinemia
| Autor: | Haq Nawaz, Iqra Naseem, Mubashir Nawaz, Tanzila Rehman |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Chemistry
Bilirubin Photodissociation Biomedical Engineering Medicine (miscellaneous) chemistry.chemical_element Nanoparticle Bioengineering 02 engineering and technology Zinc Development 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences In vitro 0104 chemical sciences Catalysis chemistry.chemical_compound In vivo General Materials Science 0210 nano-technology Uv treatment Nuclear chemistry |
| Zdroj: | Nanomedicine. 16:1377-1390 |
| ISSN: | 1748-6963 1743-5889 |
| DOI: | 10.2217/nnm-2021-0036 |
| Popis: | Aim: To optimize the Zinc oxide nanoparticles (ZnONPs)-catalyzed in vitro photolysis of bilirubin and to test their effect on bilirubin clearance in vivo. Materials & methods: ZnONPs, synthesized in an alkaline medium, were characterized. Response surface methodology was used to optimize the in vitro photolysis catalyzed by the nanoparticles (NPs). Blood samples from phenylhydrazine-induced hyperbilirubinemic rabbits which had been administered ZnONPs and UV light were analyzed to assess in vivo clearance of bilirubin. Results: The ZnONP-assisted UV treatment showed the linear and quadratic positive effects on the in vitro bilirubin photolysis with an optimal photolysis of bilirubin at 225 mg dl-1 concentration of ZnONPs and a UV exposure of 1.80 h. The ZnONP-assisted phototherapy of hyperbilirubinemic animals was also found to be more effective for in vivo clearance of bilirubin than phototherapy alone. Conclusion: After further trials, ZnONP-assisted phototherapy could be a potential treatment for hyperbilirubinemia in humans. |
| Databáze: | OpenAIRE |
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