Some characteristics of the mechanism of action of copper (II) complexes withα-amino acids
| Autor: | G. I. Potapova, E. M. Treshchalina, N. V. Matveichuk, N. O. Gudratov |
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| Rok vydání: | 1985 |
| Předmět: |
chemistry.chemical_classification
DNA synthesis medicine.medical_treatment Intraperitoneal injection Spleen General Medicine Pharmacology General Biochemistry Genetics and Molecular Biology Amino acid chemistry.chemical_compound medicine.anatomical_structure Mechanism of action Biosynthesis chemistry Biochemistry Toxicity medicine medicine.symptom Thymidine |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 99:105-107 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | On the basis of the supposed difference in the mechanisms of action of copper (II) complexes with alpha-amino acids and of alkylating agents, the antitumor activity of Cu-2 when given in conjunction with cis-diamminedichloroplatinum (DDP) is studied. The DNA precursor C 14-thymidine was injected into mice 30 min before sacrifice. Doses of the substances appropriate as regards toxicity were used: Cu-2 9 mg/kg, DPP 4 mg/kg. The antitumor effect was assessed as inhibition of tumor growth, calculated relative to the mean volumes of the tumor in the experimental animals, was compared with the controls over a period of time. Toxicity was recorded as the percentage of mice which died and changes in the mean weight of the spleen. The investigations show that Cu-1 does not induce direct inhibition of DNA synthesis in the tumor cell, unlike DDP and sarcolysin. Combined administration of Cu-2 and DDP leads to summation of their antitumor effect without any increase in toxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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