Adriamycin and 1-(2-Chlorethyl)-3-Cyclohexyl-1-Nitrosourea (CCNU) in the treatment of metastatic breast cancer
| Autor: | Aman U. Buzdar, Charles K. Tashima, Gabriel N. Hortobagyi, George R. Blumenschein, Michael A. Burgess, William C. Waterfield |
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| Rok vydání: | 1978 |
| Předmět: |
Oncology
Cancer Research Chemotherapy medicine.medical_specialty Nitrosourea business.industry medicine.medical_treatment Spontaneous remission Lomustine medicine.disease Metastatic breast cancer chemistry.chemical_compound chemistry Internal medicine medicine Every Three Weeks Doxorubicin business Every Six Weeks medicine.drug |
| Zdroj: | Cancer. 41:1235-1239 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(197804)41:4<1235::aid-cncr2820410403>3.0.co;2-8 |
| Popis: | Adriamycin every three weeks and CCNU every six weeks were given to thirty patients with metastatic breast carcinoma. Most patients had received prior chemotherapy. The overall response rate was 40%, with three patients obtaining complete remission. Survival was significantly prolonged in responders versus nonresponders. Three patients developed CNS metastasis while on treatment. Prior chemotherapy was a major factor in determining response rate; all patients without prior chemotherapy responded. The combination appears to be inferior to adriamycin alone in patients who have received prior chemotherapy. |
| Databáze: | OpenAIRE |
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