Structure and cytotoxicity of biodegradable poly(d,l-lactide-co-glycolide) nanoparticles loaded with oxaliplatin

Autor:	Kirill T. Kalinin, Ekaterina V. Razuvaeva, Sergei N. Chvalun, Dmitry S. Volkov, Nikita G. Sedush, Alexey A. Nazarov
Rok vydání:	2021
Předmět:	Morphology (linguistics) Chemistry Nanoparticle General Chemistry digestive system diseases In vitro Oxaliplatin stomatognathic diseases Cancer cell Copolymer medicine Selectivity Cytotoxicity neoplasms Nuclear chemistry medicine.drug
Zdroj:	Mendeleev Communications. 31:512-514
ISSN:	0959-9436
DOI:	10.1016/j.mencom.2021.07.025
Popis:	Spherical nanoparticles based on the biocompatible and biodegradable poly(d,l-lactide-co-glycolide) copolymer (90 : 10) loaded with oxaliplatin were produced by nanoprecipitation. Effect of the oxaliplatin loading on structure, size and morphology of the copolymer particles is considered. The nanoformulation of oxaliplatin demonstrates enhanced cytotoxicity and selectivity in vitro against several cancer cells compared with the free drug.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b77b9974afbbfa9681338f0260959d99 https://doi.org/10.1016/j.mencom.2021.07.025 Zobrazit plný text záznamu Full Text from ScienceDirect