Abstract 3439: Sarcomatoid renal cell carcinoma as a biological example of epithelial to mesenchymal transition (EMT)
| Autor: | Christina Möller, Martin Johansson, Elise Nilsson, Håkan Axelson, Anna-Karin Boström |
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| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Cancer Research. 71:3439-3439 |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/1538-7445.am2011-3439 |
| Popis: | About 8% of clear cell renal cell carcinoma (CCRCC) cases contain areas of a radically different morphology, demonstrating spindle shaped cells and a histological resemblance to sarcomas. These biphasic neoplasms are called sarcomatoid CCRCC (sCCRCC). Patients diagnosed with sCCRCC face a considerably worse prognosis due to an increased propensity for metastasis. Using a set of biphasic CCRCC cases, we showed that sCCRCC has a higher proliferative index and more prononced vimentin expression as compared to the CCRCC counterpart. We selected a CCRCC/sCCRCC case demonstrating overgrowth as well as metastatic spread for extended immunohistochemical characterization. Using mouse xenografts we evaluated a $$$$CCRCC cell-line and put forward the hypothesis that some CCRCC cell-lines may be derived from the sarcomatoid component rather than from the clear cell part, with obvious implications for the validity of in vitro models of CCRCC. We confirm that sCCRCC is derived from the clear cell component and show that sCCRCC morphologically and immunohistochemically may represent a completed epithelial mesenchymal transition (EMT). Furthermore we suggest that TGF-β1 may be the driving force behind sarcomatoid transdifferentiation i.e. EMT in CCRCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3439. doi:10.1158/1538-7445.AM2011-3439 |
| Databáze: | OpenAIRE |
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