| Autor: |
Leonida Arro, C-R. Salenstedt |
| Rok vydání: |
1973 |
| Předmět: |
|
| Zdroj: |
Journal of Biological Standardization. 1:87-99 |
| ISSN: |
0092-1157 |
| DOI: |
10.1016/0092-1157(73)90034-6 |
| Popis: |
The toxicity of four different ‘cationic’ quaternary ammonium compounds was tested in cultures of primary monkey kidney cells and in mice and rabbits. The results showed that the compounds were considerably toxic to tissue cultures—a final dilution of 1:40,000 being toxic everywhere. The relative toxicity 1 : 4 : 10 : 20–35 indicated that there were marked differences between the quaternaries. The titrations also showed that the toxic action was time dependent. The lethal dose in mouse tests varied from 10 to 35 mg/kg body weight. The skin test in rabbits gave almost identical level of toxicity for all compounds. Reactions were not observed with dilutions ⩾ 1 8100 when the test period varied between 1 and 13 days. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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