Fat and Bone: PGC-1α Regulates Mesenchymal Cell Fate during Aging and Osteoporosis
| Autor: | Steven M. Tommasini, Mark C. Horowitz |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Stromal cell Cellular differentiation Osteoporosis Mesenchymal stem cell Adipose tissue Cell Biology Biology medicine.disease Skeleton (computer programming) Cell biology 03 medical and health sciences 030104 developmental biology Adipogenesis Gene expression Genetics medicine Molecular Medicine |
| Zdroj: | Cell Stem Cell. 23:151-153 |
| ISSN: | 1934-5909 |
| Popis: | PGC-1α is a transcriptional co-activator associated with PPARγ that regulates thermogenic gene expression in brown fat. In this issue, Yu et al. (2018) show that PGC-1α regulates marrow mesenchymal stromal cell lineage allocation in vivo, inhibiting marrow adipogenesis and associated bone loss in the aging skeleton and following ovariectomy-induced osteoporosis. |
| Databáze: | OpenAIRE |
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