HbA1cmeasurement for the diagnosis of diabetes: is it enough?
| Autor: | J. Comerlato, Paula Breitenbach Renz, Gabriela Cavagnolli, J. L. Gross, Joiza Lins Camargo, Carolina Baldisserotto Comerlato |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Diagnostic methods Receiver operating characteristic Clinical pathology business.industry Endocrinology Diabetes and Metabolism Diagnostic test medicine.disease Obesity Surgery chemistry.chemical_compound Endocrinology chemistry Diabetes mellitus Internal medicine Internal Medicine Medicine Glycated hemoglobin Oral glucose tolerance business |
| Zdroj: | Diabetic Medicine. 28:31-35 |
| ISSN: | 0742-3071 |
| DOI: | 10.1111/j.1464-5491.2010.03159.x |
| Popis: | Diabet. Med. 28, 31–35 (2011) Abstract Aim To analyse the performance of HbA1c in diagnosing Type 2 diabetes based on fasting plasma glucose and/or 2-h plasma glucose measurements after a 75-g oral glucose tolerance test. Methods This is a study of diagnostic test accuracy in individuals referred to the Clinical Pathology Department for oral glucose tolerance testing. After fasting overnight, HbA1c, fasting plasma glucose and 2-h plasma glucose were measured. The receiver operating characteristic curve was used to evaluate the diagnostic performance of HbA1c. Results Four hundred and ninety-eight subjects (195 male, mean age 56 years) were enrolled and 115 (23.1%) were diagnosed with diabetes according to glucose-based methods and only 56 (11.2%) individuals were identified by HbA1c≥ 6.5% (48 mmol/mol) (sensitivity 20.9%, specificity 95.3%). There is poor agreement between the newly recommended criterion and the current glucose-based diagnostic criteria (κ = 0.217; P |
| Databáze: | OpenAIRE |
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