Modification of Mutagenic Activity of Anticancer Drugs
| Autor: | J. Revazova, L. Radchenko, G. Muravnik |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Diminution
endocrine system Chemical compound Polyvinylpyrrolidone Chemistry fungi food and beverages Sperm abnormality Pharmacology Anticancer drug chemistry.chemical_compound medicine.anatomical_structure Dominant lethal medicine Bone marrow Bone marrow cell reproductive and urinary physiology medicine.drug |
| Zdroj: | Archives of Toxicology ISBN: 9783540101918 |
| Popis: | The ability of polyvinylpyrrolidone to decrease mutagenic effects of some anticancer drugs (fotrine and fopurine) has been demonstrated in mammals. The reduction of mutagenic effects of these chemicals by combination with polyvinylpyrrolidone has been discovered in a dominant lethal test, in a sperm abnormality test and in cytogenetic analysis in bone marrow cells from mammals. The diminution of mutagenicity is pronounced with use of higher doses of the chemicals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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