Organocatalytic α-trifluoromethylthiolation of silylenol ethers: Batch vs continuous flow reactions
| Autor: | Said Said Abubakar, Sergio Rossi, Maurizio Benaglia, Rita Annunziata |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
010405 organic chemistry
Continuous flow General Chemistry Flow chemistry 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Computational chemistry Reagent Organocatalysis Batch processing Organic chemistry Lewis acids and bases Tetrahydrothiophene |
| Zdroj: | Catalysis Today. 308:94-101 |
| ISSN: | 0920-5861 |
| DOI: | 10.1016/j.cattod.2017.09.013 |
| Popis: | This work describes the organocatalytic α-trifluoromethylthiolation of silylenol ethers using N-(trifluoromethylthio)saccharin as trifluoromethylthiolating reagent that is activated by the presence of catalytic amounts of a Lewis base. Tetrahydrothiophene was identified as the best organocatalyst and it was successfully employed to promote the synthesis of different α-trifluoromethylketones; the reaction has been performed under a traditional batch methodology and under continuous flow conditions. In general, yields obtained using the traditional batch process were higher than those observed when the reaction was performed under flow conditions. However, short reaction times, higher productivity and higher space time yields were observed when a flow system process was employed. Preliminary DFT calculations were also performed in order to elucidate the mechanism of the reaction. |
| Databáze: | OpenAIRE |
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