AN EFFICIENT THREE COMPONENT ONE-POT SYNTHESIS OF -1,2,3,4-TETRAHYDRO-4-OXO- 6-(5-SUBSTITUTED 2-PHENYL-1H-INDOL-3-YL)-2-THIOXOPYRIMIDINE-5-CARBONITRILE AS ANTIMICROBIAL AND ANTITUBERCULAR AGENTS

Autor:	Prabhaker Walmik
Rok vydání:	2021
Předmět:	Pharmacology Chemistry Component (thermodynamics) One-pot synthesis Pharmaceutical Science Pharmacology (medical) Antimicrobial Combinatorial chemistry
Zdroj:	Asian Journal of Pharmaceutical and Clinical Research. :94-97
ISSN:	2455-3891 0974-2441
DOI:	10.22159/ajpcr.2021.v14i1.39418
Popis:	Objective: The objective of the study was to synthesis of 1,2,3,4-tetrahydro-4-oxo-6-(5-substituted 2-phenyl-1H-indol-3-yl)-2-thioxopyrimidine-5- carbonitrile derivatives (4a-c). Methods: The structures of all these unknown compounds have been confirmed with the help of physical and spectral techniques such as IR, 1H, and 13C NMR and mass spectral data and these newly synthesized compounds were evaluated for in-vitro antimicrobial and antitubercular activities. Results: Screening studies have demonstrated that the newly synthesized compound 4a exhibited promising antimicrobial and antitubercular properties. Conclusion: The final results revealed that compound 4a exhibited promising antimicrobial and antitubercular properties when compared to the standard drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b741e38744bed3a7739ee7dd9862b7a0 https://doi.org/10.22159/ajpcr.2021.v14i1.39418 Zobrazit plný text záznamu