Syntheses of Cerulenin and Its Analogs. I. Cerulenin and Its Analogs with Modified Side Chain

Autor:	Shigenobu Okuda, Rumiko Shimazawa, Naoko Morisaki, Akira Kanematsu, Hiroshi Funabashi, Jun Furukawa, Toshiaki Ando, Shigeo Iwasaki
Rok vydání:	1992
Předmět:	chemistry.chemical_classification Stereochemistry medicine.drug_class Acetal Fatty acid Carboxamide General Chemistry General Medicine Optically active Aldehyde Cerulenin chemistry.chemical_compound Enzyme chemistry Drug Discovery Side chain medicine lipids (amino acids peptides and proteins)
Zdroj:	Chemical and Pharmaceutical Bulletin. 40:2945-2953
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.40.2945
Popis:	Optically active cerulenin 1, a potent inhibitor of fatty acid synthetase, was prepared via the condensation of the epoxy aldehyde 8 and the alkenyl lithium 16. In order to evaluate the effects of (E, E)-1, 4-double bounds of the cerulenin side chain on the interaction with the enzyme, a series of optically active cerulenin analogs 32a-i with modified side chains and tetrahydrocerulenin 3 were synthesized by similar procedures.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b7293aded8950b16cf49ce22a5fdba11 https://doi.org/10.1248/cpb.40.2945 Zobrazit plný text záznamu