Hemolytic efficiency of cell-bound IgM: evidence that IgM-C1 complexes activate C4 molecules not hemolytic with homologous C2--C9

Autor:	R Ejzemberg, T Borsos
Rok vydání:	1982
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 128:1600-1602
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.128.4.1600
Popis:	The hemolytic efficiency of rabbit-anti-Forssman IgM antibody depends on the source of complement components. With whole guinea pig complement as few as one in 10 IgM molecules was hemolytic; it was found that with purified guinea pig C1, C4, and C2 components and with rat late-acting components, all IgM molecules were hemolytic. Evidence indicates that the block occurred as a result of generating at least two different cell-bound C4 molecules, one of which was not competent with homologous late-acting components.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b727a1e534867637acbaa3702f2e18c5 https://doi.org/10.4049/jimmunol.128.4.1600 Zobrazit plný text záznamu