Multiple Myeloma Among Atomic Bornb Survivors in Hiroshima and Nagasaki, 1950–76: Relationship to Radiation Dose Absorbed by Marrow2
| Autor: | Masako Matsunaga, Michito Ichimaru, Toranosuke Ishimaru, Motoko Mikami |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty business.industry Incidence (epidemiology) Absolute risk reduction social sciences medicine.disease humanities Leukemia Dose–response relationship medicine.anatomical_structure Internal medicine Relative risk Cohort medicine Bone marrow Nuclear medicine business Multiple myeloma |
| Zdroj: | JNCI: Journal of the National Cancer Institute. |
| ISSN: | 1460-2105 |
| Popis: | The relationship between atomic bomb exposure and the incidence of multiple myeloma has been examined in a fixed cohort of atomic bomb survivors and controls in the life-span study sample for Hiroshima and Nagasaki. From October 1950 to December 1976, 29 cases of multiple myeloma were confirmed in this sample. Our analysis shows that the standardized relative risk (RR) adjusted for city, sex, and age at the time of bombings (ATB) increased with marrow-absorbed radiation dose. The increased RR does not appear to differ between cities or sexes and is demonstrable only for those survivors whose age ATB was between 20 and 59 years. The estimated risk in these individuals is approximately 0.48 cases/million person-years/rad for bone marrow total dose. This excess risk did not become apparent in individuals receiving 50 rad or more in marrow total dose until 20 years or more after exposure. |
| Databáze: | OpenAIRE |
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