Metabolic and Histopathological Alterations in the Fruit-Eating BatArtibeus lituratusInduced by the Organophosphorous Pesticide Fenthion

Autor:	Mirlaine S. Barros, Marcela C. Silva, Clóvis Andrade Neves, Leandro S. Goulart, Mariella Bontempo Freitas, T F Carvalho, Marcelo Coutinho Picanço, Thales S. Amaral
Rok vydání:	2012
Předmět:	Fenthion Glycogen Metabolism Pesticide Biology Toxicology Metabolic pathway chemistry.chemical_compound medicine.anatomical_structure chemistry Vacuolization Hepatocyte medicine Animal Science and Zoology Food science Organophosphorous pesticide
Zdroj:	Acta Chiropterologica. 14:225-232
ISSN:	1733-5329 1508-1109
DOI:	10.3161/150811012x654420
Popis:	The organophosphorous (OP) pesticide fenthion is widely used in commercial fruit industry and orchards in South America. Among the metabolic effects in mammals caused by fenthion, hyperglycemia occurs via the activation of hepatic metabolic pathways, which may interfere with the function of several organs and systems. The purpose of this study was to evaluate the effects of acute and sub-chronic levels of fenthion on energy metabolism and liver morphology of frugivorous bats (Artibeus lituratus), which usually feed on fruits cultivated on South American plantations where fenthion is used. Animals were fed fruit treated with fenthion by immersion of fruit in a solution containing fenthion (500 ppm) and an adhesive spreader (200 ppm). Blood glucose levels did not change due to fenthion treatment, but muscle glycogen content increased and carcass fatty acids decreased after acute exposure. An increase in hepatocyte cell diameter further characterized as an increase in vacuolization was observed. The results ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b71ae32edc5a9e3f6374481928f8070a https://doi.org/10.3161/150811012x654420 Zobrazit plný text záznamu