Immunological markers and Helicobacter pylori in patients with stomach cancer: Expression and correlation
| Autor: | Miriam Idalia Torres-Ruiz, Rodolfo González-Segovia, Luis Ariel Waller-Gonzalez, Javier Torres-López, Jesús Guillermo Espinoza-Contreras, Javier Ventura-Juárez, Martín Humberto Muñoz Ortega, José De Jesús Ramírez-García, Juan Ernesto López-Ramos, Elizabeth Verónica Moreno-Córdova, María Eugenia Vargas-Camaño |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
biology Oncogene business.industry General Neuroscience Cancer Inflammation General Medicine Helicobacter pylori bacterial infections and mycoses biology.organism_classification medicine.disease Gastroenterology digestive system diseases General Biochemistry Genetics and Molecular Biology RAR-related orphan receptor gamma Internal medicine Medicine CagA Interleukin 17 General Pharmacology Toxicology and Pharmaceutics medicine.symptom business Stomach cancer |
| Zdroj: | Biomedical Reports. |
| ISSN: | 2049-9442 2049-9434 |
| DOI: | 10.3892/br.2020.1285 |
| Popis: | Programmed death-ligand 1 (PD-L1) and ICOS-L (also referred to as B7 homolog 1 and 2, respectively) modulate the immune inflammatory response. The aim of the present study was to examine the expression levels of these inflammatory mediators in two groups of patients with an Helicobacter pylori (H. pylori) infection; patients with and without gastric cancer. The association between bacterial virulence factors, CagA and VacA, was also examined, as well as their correlation with the inflammatory profile. Endoscopy analysis indicated that 18 patients suffered from cancer and 28 patients suffered from other gastric pathologies. PCR and reverse transcription-quantitative PCR were used to analyze gastric biopsies and determine the expression levels of the inflammatory modulators PD-L1 and ICOS-L, transcription factors, cytokines and other genes associated with inflammation and pathogenicity. All 46 patients were determined positive for markers of H. pylori. Patients with stomach cancer had lower levels of ICOS-L (P |
| Databáze: | OpenAIRE |
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