Incidence, time of occurrence and response to heart failure therapy in patients with anthracycline cardiotoxicity

Autor: Nicholas Collins, A. Khan, Aadil Rahim, Ian Renner, Mumtaz Hussain, Rajinder Singh Harjit Singh, A. Ashraf, Walid Rostom
Rok vydání: 2017
Předmět:
Zdroj: Internal Medicine Journal. 47:104-109
ISSN: 1444-0903
DOI: 10.1111/imj.13305
Popis: Background Anthracyclines are commonly used chemotherapeutic medications. In the current analysis we evaluated all-cause mortality and incidence, timing and response to medical therapy of anthracycline cardiotoxicity. Methods Left ventricular ejection fraction (LVEF) was serially assessed using gated heart pool scan/echocardiography in patients receiving anthracycline based chemotherapy from January 2009 to December 2014. Results A total of 1204 patients were administered anthracyclines during the study period. During a median follow up of 32 (IQR: 15 – 58) months, all-cause mortality was 38% (n = 463) with the incidence of cardiotoxicity 10.2% (n = 123). Only 15.4% (n = 19) patients required heart failure hospitalization with 48% (n = 59) of patients commenced on beta blockade therapy and/or angiotensin converting enzyme inhibitors. The majority of patients (73.2%, n = 90) experienced cardiotoxicity within 1 year of anthracycline initiation. The proportion of patients with complete, partial and no LVEF recovery were 16.3% (n = 20), 29.3% (n = 36) and 54.4% (n = 67) respectively. Mortality was higher in the cardiotoxicity group (49% vs 37%, p
Databáze: OpenAIRE
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